In physiologic anisocoria, the difference in pupil size does not change under bright or dim light. Typically, with physiologic anisocoria, the difference in pupil size between the two eyes does not exceed one millimeter. Anisocoria that is NOT associated with or due to an underlying medical condition is called physiologic anisocoria. The amount of anisocoria can vary from day-to-day and can even switch eyes. Up to 30% of the normal population has anisocoria.
The presence of anisocoria can be normal (physiologic), or it can be a sign of an underlying medical condition. The term anisocoria refers to pupils that are different sizes at the same time. Normally the size of the pupil is the same in each eye, with both eyes dilating or constricting together. Is it normal to have pupils of different sizes? 1: The iris is the colored part of the eye. When in a bright room or outdoors the pupil usually gets smaller (or constricts) conversely when in a dark room the pupil usually gets bigger (or dilates) to allow more light to enter the eye. The empty hole in the middle, which allows light to enter the eye, is called the pupil. It is a circular muscle, similar in shape to a donut. The colored part of the eye is called the iris.
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